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首页> 外文OA文献 >Amygdala, Hippocampus, and Ventral Medial Prefrontal Cortex Volumes Differ in Maltreated Youth with and without Chronic Posttraumatic Stress Disorder.
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Amygdala, Hippocampus, and Ventral Medial Prefrontal Cortex Volumes Differ in Maltreated Youth with and without Chronic Posttraumatic Stress Disorder.

机译：amygdala，Hippocampus和腹侧内侧前额叶皮质体积受虐待的青少年有和没有慢性创伤后应激障碍。

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Posttraumatic stress disorder (PTSD) is considered a disorder of recovery where individuals fail to learn and retain extinction of the traumatic fear response. In maltreated youth, PTSD is common, chronic, and associated with comorbidity. Studies of extinction-related structural volumes (amygdala, hippocampus, anterior cingulate cortex (ACC), and ventral medial prefrontal cortex (vmPFC)) and this stress diathesis, in maltreated youth were not previously investigated. In this cross-sectional study, neuroanatomical volumes associated with extinction in maltreated youth with PTSD (N=31), without PTSD (N=32), and in non-maltreated healthy volunteers (n=57) were examined using magnetic resonance imaging. Groups were sociodemographically similar. Participants underwent extensive assessments for strict inclusion/exclusion criteria and DSM-IV disorders. Maltreated youth with PTSD demonstrated decreased right vmPFC volumes compared with both maltreated youth without PTSD and non-maltreated controls. Maltreated youth without PTSD demonstrated larger left amygdala and right hippocampal volumes compared with maltreated youth with PTSD and non-maltreated control youth. PTSD symptoms inversely correlated with right and left hippocampal and left amygdala volumes. Confirmatory masked voxel base morphometry analyses demonstrated greater medial orbitofrontal cortex gray matter intensity in controls than maltreated youth with PTSD. Volumetric results were not influenced by psychopathology or maltreatment variables. We identified volumetric differences in extinction-related structures between maltreated youth with PTSD from those without PTSD. Alterations of the vmPFC may be one mechanism that mediates the pathway from PTSD to comorbidity. Further longitudinal work is needed to determine neurobiological factors related to chronic and persistent PTSD, and to PTSD resilience despite maltreatment.
机译：创伤后应激障碍（PTSD）被认为是一种恢复性疾病，个体无法学习并保持创伤性恐惧反应的消亡。在受虐待的年轻人中，PTSD是常见，慢性的，并伴有合并症。先前未进行过关于绝育相关结构体积（扁桃体，海马，前扣带回皮质（ACC）和腹内侧前额叶皮质（vmPFC））和这种应力素质的研究。在这项横断面研究中，使用磁共振成像检查了患有PTSD的受虐待青年（N = 31），没有PTSD（N = 32）和未受虐待的健康志愿者（n = 57）与绝种相关的神经解剖学体积。群体在社会人口统计学上相似。参与者接受了严格的纳入/排除标准和DSM-IV障碍的广泛评估。与没有PTSD的虐待青年和未虐待的对照组相比，患有PTSD的虐待青年表现出右vmPFC量减少。与没有PTSD的虐待青年相比，没有PTSD的虐待青年表现出更大的左杏仁核和右海马体积。 PTSD症状与左右海马和左杏仁核体积成反比。验证性掩盖体素基本形态分析表明，与受虐待的PTSD青年相比，对照组的眶额皮质皮层灰质强度更高。体积结果不受心理病理学或虐待变量的影响。我们确定了患有PTSD的受虐待青年与没有PTSD的青年之间在灭绝相关结构上的体积差异。 vmPFC的改变可能是介导从PTSD到合并症的途径的一种机制。需要进一步的纵向研究来确定与慢性和持续性PTSD相关的神经生物学因素，以及尽管受到虐待仍与PTSD弹性相关的神经生物学因素。

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